Study on Antibiotic Susceptibility of Ureaplasma Urealyticum in the Concentration of MIC Breakpoints for Highly Sensitivity

Objective: To study the antibiotic susceptibility of ureaplasma urealyticum in the concentration of MIC breakpoints for highly sensitivity. Methods: According to the determining MIC range of antibiotics against ureaplasma urealyticum (UU), MICs breakpoint for highly susceptibility was chosen as the final antibiotic concentration in the broth of UU in order to observe the growth of six isolated UU resistant strains. After the incubation with antibiotics for 12 h, sensitivity was judged empirically depending on the pH indicator. Results: The antimicrobiol susceptibility of these screened strains in vitro was well consistent with the retrospective analysis clinically, which supported the hypothesis that ≤ 4.0 μg/mL for tetracycline group, ≤ 0.5 μg/mL for macrolides, ≤2.0 μg/mL for ciprofloxacin and ≤1.0 μg/mL for ofloxacin were considered highly sensitive to UU in vitro. Conclusion: The result will be applied to commercial kits which may simplify the procedure of testing the susceptibility of UU.