The analysis on the characteristics distribution of T lymphocyte subsets of patients with myelodysplastic syndrome

Objective:To detecte and analyze the distribution of T lymphocyte subsets of patients with myelodysplastic syndrome(MDS) and assess the immune function of patients with MDS.Methods:Detecting the T lymphocyte subsets from peripheral blood of 35 cases of MDS patients and 10 normal controls by 500 Flow Cytometry.Results:The expression of helper T cell(Th),helper T cell/T suppressor cell(Th/Ts) and natural killer cell(NK) in MDS patients are lower than the control group,the expressions of T suppressor cell(Ts) in MDS patients are higher than the control group.The expressions of Ts cells are gradually increasing with the progression of the disease.The difference between RA/RAS and RAEB are statistically significant(P=0.027).The differences of Th,Th/Ts and NK cells in each group are not statistically significant.Conclusion:Th,Ts and NK cells participate in human immune function,dysfunction of T lymphocyte subsets may cause the immune disorder,Th,Ts and Th/Ts may be the indicator of monitoring immune function and reflecting immune status.