Progress of pathogenesis and treatment in childhood hypoproteinemia

Hypoproteinemia is a common clinical manifestation,which could affect prognosis of many diseases.It is an important prediction index of mortality,morbidity in critically ill children.Serum albumin level is closely related to the severity and mortality.In pediatric practice,hypoalbuminemia is also seen as a common feature of acute infection.Therefore,the clinical interventions of hypoalbuminemia in critically ill children should be emphasized,which plays a crucial role in reducing the mortality rate.At present,the pathogenesis of hypoalbuminemia has not yet been fully clarified,so the treatment of hypoproteinemia still remains controversy.In this article,the clinical significance,pathogenesis and treatment of childhood hypoalbuminemia are reviewed.