2007•Journal of Zhengzhou UniversityRequires access
Expression of osteopontin and uPA in gastric carcinoma tissue
Zhao Zhi-guo
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Abstract
Aim:To investigate the expressions of osteopontin(OPN) and urokinase-type plasminogen activator(uPA) and their relation to the invasiveness and metastasis of gastric carcinoma.Methods:The expression of OPN and uPA in 67 cases of gastric carcinoma tissue and 20 cases of adjacent normal tissue was detected using immunohistochemistry method.Results:In gastric cancer tissue,the positive expression rates of OPN and uPA were 70.1%(47/67) and 64.2%(43/67),respectively.The expression of OPN and uPA was related to histological type,pathological stage,invasion depth,lymphatic and distant metastasis(P0.05),but not related to age,sex or differentiation degree(P0.05).The expression of OPN was positively correlated with that of uPA in gastric carcinoma tissue(rs=0.669,P0.05).Conclusion:Both OPN and uPA are significantly related to the invasiveness and metastasis of gastric carcinoma.The expression of them can reflect the biological characteristics of gastric carcinoma and could be used as important indicator in prognosis of gastric carcinoma.