Preliminary study of cerebral oxygen metabolism in the patients of acute cerebral infarction

Objective To investigate the changes of cerebral oxygen metabolism and their clinical value in acute cerebral infarction. Methods Twenty four patients with acute cerebral infarction were assigned into severe group(GCS≤8) and mild-moderate group(GCS8)according to Glasgow Coma Scale(GCS),Blood samples were obtained via jugular vein catheter and oxygen saturation (SjvO_2) was measured.Simultaneously pulse blood oxygen saturations (SpO_2) was also measured.Arteriovenous oxygen content difference (AVDO_2) and oxygen extraction fraction (OEF) were studied.These three parameters were compared between two the groups,and their correlation with GCS and GCS-P was analyzed. Results The SjvO_2 in severe group was (76 ± 6)%,higher than that in mild-moderate group (69 ± 4)%,while the OEF in severe group was lower than that in mild-moderate group (P 0.05).The SjvO_2 was persistently higher than 70% in most of severe patients,while temporarily higher in most mild-moderate patients.OEF was positively correlated with GCS and GCS-P (P 0.05).The possibility of unfavourable prognosis in the patients with SjvO_2≥70% was higher than those with SjvO_270% (P 0.05). Conclusion SjvO_2 can reflect cerebral oxygen metabolism and cerebral blood flow objectively,and predict the prognosis of acute cerebral infarction.