Clinical value of oxygen extraction fraction in old patients with acute cerebral infarction

Objective To investigate the changes of cerebral oxygen extraction fraction(OEF) following acute cerebral infarction and its clinical value in old patients.Methods Fifty-eight old patients with acute cerebral infarction of carotid artery system were divided into two groups:severe group(GCS≤8,32 cases) and non-severe group(GCS8,26 cases).Blood samples were obtained through jugular catheter and then jugular vein blood oxygen saturation(SjvO_2) was measured. Simultaneously pulse blood oxygen saturation was measured and OEF was calculated.SjvO_2 and OEF were compared between two groups.The relationships of the two parameters with GCS. GCS-P and GOS were analyzed.The value of OEF for predicting prognosis was investigated.Results SjvO_2 was significantly higher in severe group than in non-severe group(P0.01).while OEF was significantly lower in severe group than in non-severe group(P0.01).SjvOv was negatively correlated with GCS,GCS-P and GOS(P 0.01),while OEF was positively correlated with GCS,GCS-P and GOS(P 0.01).Unfavourable prognosis incidence was higher in the patients with OEF≤30%than in those with OEF30%(P 0.01).Conclusions For old patients with acute cerebral infarction of carotid artery system,OEF is a valuable parameter for evaluating degree of cerebral function injury and predicting prognosis.