EXPRESSION AND CLINICAL SIGNIFICANCE OF P-gp IN ACUTE LYMPHOBLASTIC LEUKEMIA

Objective:To detect the expression of P plycoprotein (P gp) in acute lymphoblastic leukemia (ALL) and evaluate the relationship between P gp expression and prognosis of ALL.Methods:the expression of anti glycoprotein monoantibody:UIC 2 and CD 3、CD 5、CD 7、CD 10 、CD 19 、CD 13 、CD 14 、CD 33 、CD 34 in 20 patients with direct immunofluoressence assays by flow cytometry bave studiecl.The patients' leukemia cells in peripheral blood and bone marrow should be more than fifty percent.The cell lineage of non drug resistance,K562 is used as negative control.Rusults:Eight patients in 20 expressed P gp and other twelve patients did not,P gp positive rate in myeloid antigen positive cases is 33.3 %.P gp positive rate in myeloid antigen negative cases is 45.5 %. P 0.05.Two cases of T cell acute lymphoblastic leukemia expressed CD 7 and P gp at the same time.Treatment is effective in five of eight cases in P gp positive group.Treatment is effective in ten of twelve cases in P gp negative group( P 0.05),while three cases in P gp positive cases have relapsed in six months.Conclusion:P gp positive rate in ALL is 40 %.Three is not relationship between expression of P gp and myeloid antigens.The P gp expression correlates with the CD 7 expression.The P gp expression correlate with chemotherapeutic effect in ALL.P gp positive cases are prone to relapsing earlier.