Efect of intravenous diltiazem on Propofol requirements and hemodynamic changes during anesthesia induction

ObjectiveTo observe the effect of intravenous Diltiazem on Propofol requirements and hemodynamic changes during anesthesia induction. MethodsThirtty patients scheduled for general anesthesia were divided into two groups randomly: group D (n=15, i.v Diltiazem 0.1 mg/kg), group C (n=15, i.v 0.9% Sodium Chloride 10 mL). Before anesthesia induction two groups of patients were injected with Diltiazem and 0.9% Sodium Chloride respectively, then Propofol at the rate of 30 mg/kg·h was administrated to achieve the loss of patients' consciousness and continued infusing Propofol until the bispectral index scale (BIS) reached 50. Propofol requirements of the patients losing consciousness and the BIS reaching 50 were recorded. Hemodynamic changes including blood pressure (BP) and heart rate (HR) were recorded. ResultsThere were significant differences of Propofol requirements of the patients losing consciousness [group D was (1.27 ± 0.20) mg/kg and group C was (1.44 ± 0.22) mg/kg] and BIS reaching 50 [group D was (1.92 ± 0.30) mg/kg and group C was (2.16 ± 0.36) mg/kg]. (P 0.05); Change magnitude of mean blood pressure (MBP) and heart rate (HR) between preintubation and postintubation in group D was significantly less than that in group C(P 0.05). Three patients in group D and one patient in group C have blood pressure less than 50 mmHg during induction, but there were no significant differences between them. ConclusionIntravenous Diltiazem 0.1 mg/kg before induction reduces the propofol requirements, and provide stable cardiovascular state during Propofol induction.