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2004•Chinese Journal of New Drugs and Clinical RemediesRequires access

Determination of residual organic solvents in raltitrexed by capillary gas chromatography

Duan Geng

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Abstract

AIM: To establish a method for the determination of the contents of residual methanol, ether, petroleum ether, ethyl acetate, dichlor-omethane, chloroform and dimethyl formamide in raltitrexed. METHODS: A simple capillary gas chromatography method was established with FID detector. The capillary column was HP-INNOWax, using temperature program. Nitrogen was used as carrier gas. The residues were calculated by the external standard method. RESULTS: The linearities were fairly good. The average recoveries were 93.33 %-101.92 % with RSD of 0.34 %-4.96 %. The limit of detection was 2.96-3.46 ng. The contents of seven residual organic solvents in three batches of samples were complied with the specification requirements. CONCLUSION: Capillary gas chromatography method is proved to be accurate, sensitive and reliable. It is suitable to be adopted in the analysis of these tested solvents.

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AIM: To establish a method for the determination of the contents of residual methanol, ether, petroleum ether, ethyl acetate, dichlor-omethane, chloroform and dimethyl formamide in raltitrexed. METHODS: A simple capillary gas chromatography method was established with FID detector. The capillary column was HP-INNOWax, using temperature program. Nitrogen was used as carrier gas. The residues were calculated by the external standard method. RESULTS: The linearities were fairly good. The average recoveries were 93.33 %-101.92 % with RSD of 0.34 %-4.96 %. The limit of detection was 2.96-3.46 ng. The contents of seven residual organic solvents in three batches of samples were complied with the specification requirements. CONCLUSION: Capillary gas chromatography method is proved to be accurate, sensitive and reliable. It is suitable to be adopted in the analysis of these tested solvents.

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Available abstract

AIM: To establish a method for the determination of the contents of residual methanol, ether, petroleum ether, ethyl acetate, dichlor-omethane, chloroform and dimethyl formamide in raltitrexed. METHODS: A simple capillary gas chromatography method was established with FID detector. The capillary column was HP-INNOWax, using temperature program. Nitrogen was used as carrier gas. The residues were calculated by the external standard method. RESULTS: The linearities were fairly good. The average recoveries were 93.33 %-101.92 % with RSD of 0.34 %-4.96 %. The limit of detection was 2.96-3.46 ng. The contents of seven residual organic solvents in three batches of samples were complied with the specification requirements. CONCLUSION: Capillary gas chromatography method is proved to be accurate, sensitive and reliable. It is suitable to be adopted in the analysis of these tested solvents.

Key concepts: Chromatography, Chemistry, Gas chromatography, Detection limit, Capillary action, Petroleum ether, Chloroform, Flame ionization detector

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