2006•PubMedRequires access

[Chemical constituents from roots of Platycodon grandiflorum].

Lingjun Li, Zhenhua Liu, Yun Chen, Jingkui Tian

Abstract

OBJECTIVE: To study the chemical constituents from roots of Platycodon grandiflorum. METHOD: Column chromatography (silica gel, macroporous resin, sephadex LH - 20 and the preparative RP - HPLC were used to isolate the constituents. Their structures were elucidated by physical and spectral data. RESULT: Eight compounds were isolated and identified as tangeritin (1), 3-O-beta-D-glucopyranosylplatycodigenin methyl ester (2), 3-O-beta-D-glucopyranosylplaticogenic acid A lactone (3), 3-O-beta-D-glucopyranosylplatycodigenin (4), deapio-platyconic acid A lactone (5), deapio-platycodin-D (6), platycoside-G1 (7) and platycoside-E (8). CONCLUSION: Compounds 1,3 and 5 were isolated from this plant for the first time.

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Key concepts: Sephadex, Chemistry, Silica gel, Chemical constituents, Chromatography, Lactone, Column chromatography, Spectral analysis