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2009•Research and Practice on Chinese MedicinesRequires access

Determination of Trans-ferulic Acid and Cis-ferulic Acid in 7 Medicinal Materials by RP-HPLC

Tong Yong-bin

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Abstract

Objective To develop HPLC method for determination of trans-ferulic acid and cis-ferulic acid in 7 medicinal materials .Methods Analysis was carried out on a C18 (4.6mm×250mm,5μm)column eluled with acetonitrile-0.3 % acetic acid (20:80) as the mobile phase , the detection wavelength was set at 320 nm. Results The linear relationship of ferulic acid was in the range of 0.028 5～0.513 μg ( r = 0.999 9) ,the recovery was 98.17% ,RSD was 0.73%( n = 6). Conclusion The method is simple ,accurate and reproducible, and can be used for the analysis of ferulic acid in medicinal materials

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What this paper is about

Objective To develop HPLC method for determination of trans-ferulic acid and cis-ferulic acid in 7 medicinal materials .Methods Analysis was carried out on a C18 (4.6mm×250mm,5μm)column eluled with acetonitrile-0.3 % acetic acid (20:80) as the mobile phase , the detection wavelength was set at 320 nm. Results The linear relationship of ferulic acid was in the range of 0.028 5～0.513 μg ( r = 0.999 9) ,the recovery was 98.17% ,RSD was 0.73%( n = 6). Conclusion The method is simple ,accurate and reproducible, and can be used for the analysis of ferulic acid in medicinal materials

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Available abstract

Objective To develop HPLC method for determination of trans-ferulic acid and cis-ferulic acid in 7 medicinal materials .Methods Analysis was carried out on a C18 (4.6mm×250mm,5μm)column eluled with acetonitrile-0.3 % acetic acid (20:80) as the mobile phase , the detection wavelength was set at 320 nm. Results The linear relationship of ferulic acid was in the range of 0.028 5～0.513 μg ( r = 0.999 9) ,the recovery was 98.17% ,RSD was 0.73%( n = 6). Conclusion The method is simple ,accurate and reproducible, and can be used for the analysis of ferulic acid in medicinal materials

Key concepts: Ferulic acid, Chromatography, High-performance liquid chromatography, Acetic acid, Acetonitrile, Chemistry, Linear range, Detection limit

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