2009•Letters in BiotechnologyRequires access
Effects of Signal Transducer and Activator of Transcription 3 on the Tumorigenesis
Xiao Ma
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Abstract
STAT3 is an important member of the signal transducer and activator of transcription(STAT) family of transcription factors.It is a key signal transduction protein activated by numerous cytokines, growth factors and oncoproteins that controls cell proliferation, differention, development, survival and inflammation.Constitutive activation of STAT3 has been found frequently in a wide variety of human tumors and celluar transformation and tumor formation.In this article, the effects of STAT3 on the tumorigenesis were reviewed.For instance, the mechanism of constitutive activation of STAT3 in tumor cells, the mechanism of STAT3's regulation to tumor cells as a transcription factor and so on.