hERG channel function: beyond long QT
Joseph J. Babcock, Man Li
Abstract
Open-access reader
Joseph J. Babcock, Man Li
Abstract
Open-access reader
To date, research on the human ether-a-go-go related gene (hERG) has focused on this potassium channel's role in cardiac repolarization and Long QT Syndrome (LQTS). However, growing evidence implicates hERG in a diversity of physiologic and pathological processes. Here we discuss these other functions of hERG, particularly their impact on diseases beyond cardiac arrhythmia.
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To date, research on the human ether-a-go-go related gene (hERG) has focused on this potassium channel's role in cardiac repolarization and Long QT Syndrome (LQTS). However, growing evidence implicates hERG in a diversity of physiologic and pathological processes. Here we discuss these other functions of hERG, particularly their impact on diseases beyond cardiac arrhythmia.
Key concepts: hERG, Long QT syndrome, Potassium channel, Repolarization, Medicine, Cardiology, Cardiac action potential, Internal medicine