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2007•Journal of Wenzhou Medical CollegeRequires access

Effects of glucose in different concentrations on SOD,NOS and NO produced by human umbilical vein endothelial cell

Jun Guo

Open publisher page 1 citations

Abstract

Objective:To explore the effects of glucose in different concentrations on SOD, NOS and NO produced by endothelial cell. Methods: Human umbilical vein endothelial cells strain ECV304 were cultured at different high levels of glucose in vitro, and were divided into three groups: normal glucose concentration group (Ⅰ), high glucose concentration group (Ⅱ) and fluctuant high glucose concentration group (Ⅲ). The NOS.NO and SOD were detected at the end of the experiment. Results: Compared with group Ⅰ, NOS activity and NO content increased while SOD activity declined in group Ⅱ(P0.05 or P0.01).More interestingly, the change in group Ⅲ was greater than that in group Ⅱ(P0.01). Conclusion:Fluctuant high concentration of glucose can take more serious effect on inhibiting SOD and inducing NOS and NO release from endothelial cell than that of consistent high glucose.

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What this paper is about

Objective:To explore the effects of glucose in different concentrations on SOD, NOS and NO produced by endothelial cell. Methods: Human umbilical vein endothelial cells strain ECV304 were cultured at different high levels of glucose in vitro, and were divided into three groups: normal glucose concentration group (Ⅰ), high glucose concentration group (Ⅱ) and fluctuant high glucose concentration group (Ⅲ). The NOS.NO and SOD were detected at the end of the experiment. Results: Compared with group Ⅰ, NOS activity and NO content increased while SOD activity declined in group Ⅱ(P0.05 or P0.01).More interestingly, the change in group Ⅲ was greater than that in group Ⅱ(P0.01). Conclusion:Fluctuant high concentration of glucose can take more serious effect on inhibiting SOD and inducing NOS and NO release from endothelial cell than that of consistent high glucose.

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Available abstract

Objective:To explore the effects of glucose in different concentrations on SOD, NOS and NO produced by endothelial cell. Methods: Human umbilical vein endothelial cells strain ECV304 were cultured at different high levels of glucose in vitro, and were divided into three groups: normal glucose concentration group (Ⅰ), high glucose concentration group (Ⅱ) and fluctuant high glucose concentration group (Ⅲ). The NOS.NO and SOD were detected at the end of the experiment. Results: Compared with group Ⅰ, NOS activity and NO content increased while SOD activity declined in group Ⅱ(P0.05 or P0.01).More interestingly, the change in group Ⅲ was greater than that in group Ⅱ(P0.01). Conclusion:Fluctuant high concentration of glucose can take more serious effect on inhibiting SOD and inducing NOS and NO release from endothelial cell than that of consistent high glucose.

Key concepts: Umbilical vein, Human umbilical vein endothelial cell, Endocrinology, Internal medicine, Endothelial stem cell, Strain (injury), In vitro, Superoxide dismutase

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Effects of glucose in different concentrations on SOD,NOS and NO produced by human umbilical vein endothelial cell — Research Paper | ScholarLens