Curative effect observation of blood perfusion and naloxone in the treatment of hypnotic poisoning

Objective To discuss the curative effect of blood perfusion and naloxone in the treatment of hypnotic poisoning.Methods Thirty-two patients with hypnotic poisoning from January 2008 to May 2012 in our hospital were analyzed retrospectively and were randomly divided into two groups.The treatment group received blood perfusion and naloxone treatment,while the control group received routine treatment.The indices of blood pressure,heart rate,serum pH,PaO2,PaCO2,recovery time,the toxicant concentration in plasma,various complications in the two groups before treatment and after a week's treatment were observed and analyzed.Results The conditions of two groups were improved dramatically after treatment,no deaths occurred,but the curative effect of the treatment group was significantly better than that of the control group.The indices of total wake time,hospitalization time and time of plasma drug concentrations within the normal range in the treatment group were significantly lower than those in the control group.Conclusion Hemoperfusion combined with naloxone in the treatment of patients with hypnotic poisoning can significantly improve the cure rate,decrease the complications and it have fewer adverse reactions and it is worthy of clinical application.