Expressions and significances of Livin,Smac and Ki67 in epithelial ovarian carcinoma

Objective:To explore the expressions and significances of inhibitor of apoptosis protein-Livin,apoptosis related factor-Smac and proliferating cell nuclear antigen-Ki67 in epithelial ovarian carcinoma,and analyze their correlation.Methods:Immunohistochemical SP method was used to detect the expression levels of Livin,Smac and Ki67 in 50 cases with epithelial ovarian cancer,20 cases with borderline ovarian tumor,20 cases with benign ovarian tumor and 20 cases with normal ovarian tissues.Results:The expression levels of Livin and Ki67 in epithelial ovarian cancer group were significantly higher than those in the other three groups(P0.01).There was positive correlation between expression levels of Livin and Ki67 in ovarian tissues and histopathological grades,lymph node metastasis(P0.05),but they were not related to histological types and stages.The expression level of Smac in epithelial ovarian cancer group was significantly lower than those in the other three groups(P0.01).There was negative correlation between expression level of Smac in ovarian tissues and histopathological grades,lymph node metastasis(P0.05),but they were not related to histological types and stages.Conclusion:Livin,Smac and Ki67 play important roles in the occurrence,differentiation and development of epithelial ovarian cancer,which may become new targets of epithelial ovarian cancer treatment.