Expression of B7-H4 on Epithelial Ovarian Cancer and it's significances

Objective To study the expression of B7-H4 on epithelial ovarian cancer and to explore the relationship among different clinical and biologial features.Methods Using the immunohistochemistry PV-6000,we comparatively studied the expression on 70 cases of primary epithelial ovarian cancer,20 cases of normal ovarian tissue and 20 cases of benign ovarian neoplasm.Results B7-H4 cytoplasmic and/or membranous expression was detected in epithelial ovarian cancer. The positive rate of B7-H4' s expression in primary epithelial ovarian cancer,benign ovarian neoplasm and normal ovarian tissue were respectively 88.57%,45%and 0%.The differences were statistically significant.The B7-H4' s expression in epithelial ovarian cancers was relavant to differentiations,pathological types and whether lymph node metastasis or not.The differences were statistically significant.Conclusions B7-H4 overexpress in epithelial ovarian cancer,the lower differentiation the higher B7-H4' s expression,and B7-H4 expression enhanced in lymph node metastasis cases,so that B7-H4 should be further investigated as a potential diagnostic and prognostic marker for ovarian cancer.