2006•Zhongguo laonianxue zazhiRequires access
Expression of proto-oncogene in myocardial infarction of rats and intervention of Fosinopril on it
Zhi Wang
Open publisher page 0 citations
Abstract
Objective To discuss the expression of proto-oncogene in myocardial infarction of rats and effect of Fosinopril on it.Methods The acute myocardial infarction (AMI) model of rats made with coronary artery ligation were randomly divided into sham operated group,AMI model group, low dose of Fosinopril group and high dose of Fosinopril group. The cardiac muscle samples were obtained 24 h and 4 weeks after AMI to detect the expression of proto-oncogene c-myc, c-fos and c-jun mRNA by reverse transcription polymerase chain reaction (RT-PCR).Results The c-myc, c-fos and c-jun of rats had high expression and were inhibited by Fosinopril 24 h after AMI. The expression of c-myc, c-fos and c-jun of rats nearly stopped and were hardly impacted by Fosinopril 4 weeks after AMI.Conclusions The proto-oncogene has high expression in the earlier period of AMI and could be obviously inhibited by angiotensin converting enzyme inhibitor (ACEI). It is important that ACEI should be administerd as soon as possible to prevent and treat of ventricular remodeling.