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2007•Chinese Journal of PharmaceuticalsRequires access

Purification of (R)-Mandelic Acid from Fermentation Broth by Anion-Exchange Resin H401

Guo Yang-hao

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Abstract

The adsorption behavior of (R)-(-)-mandelic acid in fermentation broth on several anion-exchange resins was studied. Resin H401was chosen to separate mandelic acid due to its high ion exchange capacity and low adsorption rate for impurities. The optimum conditions for dynamic adsorption were pH 6.0 -6.5 at flow velocity of 1.0 BV/h. The optimum elution was 1% HCl at flow velocity of 0.5 BV/h. Under the optimal conditions,the recovery of (R)-mandelic acid from fermentation broth achieved 95%. The purity of recovered (R)-(-)-mandelic acid in the final eluent was over 95% and its enantiomeric excess value reached to 98.5%.

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What this paper is about

The adsorption behavior of (R)-(-)-mandelic acid in fermentation broth on several anion-exchange resins was studied. Resin H401was chosen to separate mandelic acid due to its high ion exchange capacity and low adsorption rate for impurities. The optimum conditions for dynamic adsorption were pH 6.0 -6.5 at flow velocity of 1.0 BV/h. The optimum elution was 1% HCl at flow velocity of 0.5 BV/h. Under the optimal conditions,the recovery of (R)-mandelic acid from fermentation broth achieved 95%. The purity of recovered (R)-(-)-mandelic acid in the final eluent was over 95% and its enantiomeric excess value reached to 98.5%.

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Available abstract

The adsorption behavior of (R)-(-)-mandelic acid in fermentation broth on several anion-exchange resins was studied. Resin H401was chosen to separate mandelic acid due to its high ion exchange capacity and low adsorption rate for impurities. The optimum conditions for dynamic adsorption were pH 6.0 -6.5 at flow velocity of 1.0 BV/h. The optimum elution was 1% HCl at flow velocity of 0.5 BV/h. Under the optimal conditions,the recovery of (R)-mandelic acid from fermentation broth achieved 95%. The purity of recovered (R)-(-)-mandelic acid in the final eluent was over 95% and its enantiomeric excess value reached to 98.5%.

Key concepts: Chemistry, Mandelic acid, Adsorption, Elution, Chromatography, Fermentation, Ion-exchange resin, Ion exchange

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