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Separation and Purification of R-Mandelic Acid from Ferment Broth by Ion Exchange Technology

Jianfeng Chen, Shi Yin-ying, Hao Chen, Xiao Mei-tian, BI Ming-bo, Guo Yang-hao

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Abstract

The purpose is to study a new method for the separation and purification of R-mandelic acid from ferment broth by ion exchange technology.While R-mandelic acid separated from ferment broth at 711-OH anion exchange resin,the optimum dynamic adsorption condition was 6.0～7.0 pH value,70～80 mmol/L R-mandelic acid concentration,8～10 mmol/L phenylglyoxilic acid concentration and(0.5 Bv/h) velocity of flow.The optimum dynamic desorption condition was 2% HCl concentration and 0.5 Bv/h velocity of flow.90.8% R-mandelic acid could be separated from ferment broth by this technicque.

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What this paper is about

The purpose is to study a new method for the separation and purification of R-mandelic acid from ferment broth by ion exchange technology.While R-mandelic acid separated from ferment broth at 711-OH anion exchange resin,the optimum dynamic adsorption condition was 6.0～7.0 pH value,70～80 mmol/L R-mandelic acid concentration,8～10 mmol/L phenylglyoxilic acid concentration and(0.5 Bv/h) velocity of flow.The optimum dynamic desorption condition was 2% HCl concentration and 0.5 Bv/h velocity of flow.90.8% R-mandelic acid could be separated from ferment broth by this technicque.

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Available abstract

The purpose is to study a new method for the separation and purification of R-mandelic acid from ferment broth by ion exchange technology.While R-mandelic acid separated from ferment broth at 711-OH anion exchange resin,the optimum dynamic adsorption condition was 6.0～7.0 pH value,70～80 mmol/L R-mandelic acid concentration,8～10 mmol/L phenylglyoxilic acid concentration and(0.5 Bv/h) velocity of flow.The optimum dynamic desorption condition was 2% HCl concentration and 0.5 Bv/h velocity of flow.90.8% R-mandelic acid could be separated from ferment broth by this technicque.

Key concepts: Mandelic acid, Chemistry, Chromatography, Desorption, Ion exchange, Ion-exchange resin, Adsorption, Ion

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