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2003•Chinese Journal of Current Advances in General SurgeryRequires access

A modified animal model of Orthotopic liver transplantation in the rat

Changan Liu

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Abstract

Objective:To introduce an animal model of modified cuff technique of orthotopic liver transplantation in the rat.Methods:Orthotopic liver transplantation was conducted in 110 rats by modified cuff technique.Results:The average time of acquiring donor liver was 37 minutes,repairing liver was 13 minutes,anhepatic phase was 14 minutes.Eight cases died in operation and after surgery,the operative successful rate was 93%.Eleven rats died after one week postoperatively,the survival rate was 89% after 1 week,the main causes of death were infection and obstruction of biliary tract.Conclusion:The modified cuff technique possesses advantages of short anhepatic phase,high operative successful rate,and long survival time after surgical operation,which is an ideal operative method of orthotopic liver transplantation in the rat.

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What this paper is about

Objective:To introduce an animal model of modified cuff technique of orthotopic liver transplantation in the rat.Methods:Orthotopic liver transplantation was conducted in 110 rats by modified cuff technique.Results:The average time of acquiring donor liver was 37 minutes,repairing liver was 13 minutes,anhepatic phase was 14 minutes.Eight cases died in operation and after surgery,the operative successful rate was 93%.Eleven rats died after one week postoperatively,the survival rate was 89% after 1 week,the main causes of death were infection and obstruction of biliary tract.Conclusion:The modified cuff technique possesses advantages of short anhepatic phase,high operative successful rate,and long survival time after surgical operation,which is an ideal operative method of orthotopic liver transplantation in the rat.

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Available abstract

Objective:To introduce an animal model of modified cuff technique of orthotopic liver transplantation in the rat.Methods:Orthotopic liver transplantation was conducted in 110 rats by modified cuff technique.Results:The average time of acquiring donor liver was 37 minutes,repairing liver was 13 minutes,anhepatic phase was 14 minutes.Eight cases died in operation and after surgery,the operative successful rate was 93%.Eleven rats died after one week postoperatively,the survival rate was 89% after 1 week,the main causes of death were infection and obstruction of biliary tract.Conclusion:The modified cuff technique possesses advantages of short anhepatic phase,high operative successful rate,and long survival time after surgical operation,which is an ideal operative method of orthotopic liver transplantation in the rat.

Key concepts: Medicine, Orthotopic liver transplantation, Cuff, Liver transplantation, Surgery, Rat model, Survival rate, Animal model

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