Fluvastatin and fenofibrate and fluvastatin of high dosage in management of hyperlipidemia

Objective To evaluate the efficacy and safety of combination therapy with fluvastatin and fenofibrate and high dosage of fluvastatin in patients with combined hyperlipidemia.Methods Seventy patients with combined hyperlipidemia were randomly assigned to receive 80 mg fluvastatin(n=35)or a combination of 40 mg fluvastatin and 200 mg fenofibrate(n=35) for 12 weeks.Lipid levels and adversese were assessed.Results After 12 weeks treatment,serum TC and LDL-C levels were reduced a little more in high dose of fluvastatin group than in combination therapy group,but there was no significant difference between them(P0.05).The level of TG decreased and HDL-C increased more significantly in combination therapy group than in high dose of fluvastatin group(P0.01).The success rate of TC,LDL-C and TG control in combination therapy group was superior to high dosage of fluvastatin(P0.05).Combined treatment and the high dose of fluvastatin treatment were well tolerated with no increase in adverse events.Conclusion Combination therapy with fluvastatin(40 mg·d-1) and fenofibrate(200 mg·d-1) is more effective than fluvastatin monotherapy in patients with combined hyperlipidemia,and is generally safe and well tolerated.