Significance of soluble CD14 in the patients with coronary artery disease

Objective To study the relationship of soluble CD14 with the severity of coronary ar- tery disease(CAD),and to investigate whether it is a non-invasive marker of coronary plaque destabili- zation in CAD.Methods The 3 groups included 60 cases of acute myocardial infarction(AMI group) within 14 hours after the onset,58 cases of unstable angina pectoris(UAP group)within 14 hours after the last episode,50 cases of stable angina pectoris(SAP group),and the control group consisted of 55 cases. Serum level of soluble CD14 was measured by enzyme-linked immunosorbent assay(ELISA).The differ- ences of soluble CD14 levels between different groups were observed.Linear correlation analysis was used to analyze the relationship between the level of soluble CD14 and white blood cell(WBC)in CAD patients. Results Compared with the control group,the levels of soluble CD14 were higher in AMI,UAP and SAP groups.Compared with SAP group,the levels of soluble CD14 were elevated obviously in AMI and UAP groups,while there were no significant differences between AMI group and UAP group.The levels of solu- ble CD14 were correlated with a total of peripheral WBC in CAD patiems.Conclusion Soluble CD14 can be used as a marker of the presence of coronary atherosclerosis and is involved in the pathogenesis of CAD.The levels of soluble CD14 were correlated with the severity of CAD.