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[Studies on urinary metabolites of calusterone in man].

Zhang Yz, X Liu, Zhang Cj, Ye L

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Abstract

The metabolites of calusterone (17 beta-OH-7 beta, 17 alpha-dimethyl-androst-4-ene-3-one) in man has been investigated by GC/MS. After oral administration, the parent compound and seven metabolites were detected in the conjugated fraction. The extraction and fractionation of these metabolites were achieved by using XAD-2 column. The sample was derivatized with MSTFA/TMSI before GC/MS analysis. The mass spectra of the metabolites are presented and the metabolic pathway was discussed.

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What this paper is about

The metabolites of calusterone (17 beta-OH-7 beta, 17 alpha-dimethyl-androst-4-ene-3-one) in man has been investigated by GC/MS. After oral administration, the parent compound and seven metabolites were detected in the conjugated fraction. The extraction and fractionation of these metabolites were achieved by using XAD-2 column. The sample was derivatized with MSTFA/TMSI before GC/MS analysis. The mass spectra of the metabolites are presented and the metabolic pathway was discussed.

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Available abstract

The metabolites of calusterone (17 beta-OH-7 beta, 17 alpha-dimethyl-androst-4-ene-3-one) in man has been investigated by GC/MS. After oral administration, the parent compound and seven metabolites were detected in the conjugated fraction. The extraction and fractionation of these metabolites were achieved by using XAD-2 column. The sample was derivatized with MSTFA/TMSI before GC/MS analysis. The mass spectra of the metabolites are presented and the metabolic pathway was discussed.

Key concepts: Chemistry, Chromatography, Fractionation, Extraction (chemistry), Gas chromatography–mass spectrometry, Urine, Fraction (chemistry), Metabolic pathway

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