1990•Journal of Analytical ToxicologyRequires access

Pretreatment of Urine Samples for the Analysis of 11-nor-Δ9-Tetrahydrocannabinol-9-Carboxylic Acid Using Solid-Phase Extraction

Ritchard C. Parry, L. Nolan, R. Shirey, George D. Wachob, Daryl J. Gisch

Abstract

An extraction and concentration procedure using a unique solid-phase extraction tube was developed for the analysis of 11-nor-delta 9-tetrahydrocannabinol-9-carboxylic acid in urine. Absolute and relative recoveries of the drug metabolite were found to be greater than 85% and 92%, respectively. The extraction procedure allows quantitation of the drug metabolite by GC/MS, HPLC with UV detection, or GC with flame ionization detection. The extraction procedure was verified with urine samples obtained from marijuana users as well as spiked urine samples.

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Key concepts: Chromatography, Metabolite, Urine, Chemistry, Solid phase extraction, Extraction (chemistry), Detection limit, Quantitative analysis (chemistry)