ScholarLens Back to search
2003•Zhongliu fangzhi yanjiuRequires access

Expression of basic fibroblast growth factor and fibroblast growth factor receptor-1 in human meningiomas

Yi Wei

Open publisher page 0 citations

Abstract

Objective To investigate the extent of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor 1 (FGFR 1) expression in human meningiomas and the relationship between the expression and the tumors' histological features and recurrence. Methods Expression of bFGF and FGFR 1 were examined by immunohistochemical technique. Results There is varied degree expression of bFGF and FGFR 1 protein in meningiomas. The expression correlates with the tumors' histological characters and recurrence. Conclusion FGFR 1 and bFGF may play an important role in meningiomas' proliferation. The over expression of bFGF and FGFR 1 reflects the proliferative activity of tumor. bFGF and FGFR 1 may be considered as indicators in meningiomas' histological characters and postoperative recurrence.

About this research paper

What this paper is about

Objective To investigate the extent of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor 1 (FGFR 1) expression in human meningiomas and the relationship between the expression and the tumors' histological features and recurrence. Methods Expression of bFGF and FGFR 1 were examined by immunohistochemical technique. Results There is varied degree expression of bFGF and FGFR 1 protein in meningiomas. The expression correlates with the tumors' histological characters and recurrence. Conclusion FGFR 1 and bFGF may play an important role in meningiomas' proliferation. The over expression of bFGF and FGFR 1 reflects the proliferative activity of tumor. bFGF and FGFR 1 may be considered as indicators in meningiomas' histological characters and postoperative recurrence.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To investigate the extent of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor 1 (FGFR 1) expression in human meningiomas and the relationship between the expression and the tumors' histological features and recurrence. Methods Expression of bFGF and FGFR 1 were examined by immunohistochemical technique. Results There is varied degree expression of bFGF and FGFR 1 protein in meningiomas. The expression correlates with the tumors' histological characters and recurrence. Conclusion FGFR 1 and bFGF may play an important role in meningiomas' proliferation. The over expression of bFGF and FGFR 1 reflects the proliferative activity of tumor. bFGF and FGFR 1 may be considered as indicators in meningiomas' histological characters and postoperative recurrence.

Key concepts: Fibroblast growth factor receptor, Basic fibroblast growth factor, Immunohistochemistry, Fibroblast growth factor, Fibroblast growth factor receptor 4, Fibroblast growth factor receptor 2, Fibroblast growth factor receptor 3, Fibroblast growth factor receptor 1

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Expression of basic fibroblast growth factor and fibroblast growth factor receptor-1 in human meningiomas — Research Paper | ScholarLens