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2002•Journal of Clinical Medical officerRequires access

Study of Expressions of bFGF and FGFR 1 as Well as Levelof FGFR 1 Activity in Bladder Cancer

Xie Qing

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Abstract

Objective To investigate the roles of basic fibroblast growth factor (bFGF) autocrine loop in pathogenesis of bladder cancer. Methods Expressions of bFGF and its receptor FGFR 1 and phosphotyrosine protein (P Tyr) were examined by immunohistochemistry methods in 72 cases with bladder and 16 specimens of normal bladder tissue. Results Higher expressions of bFGF, FGFR 1 and P Tyr were found in bladder than those in normal tissues, respectively. Expressions of bFGF and FGFR 1 were assocition with tumor grade, stage and recurrence. There were significantly relating expressions among bFGF, FGFR 1 and P Tyr in bladder cancer. Conclusion Abnormally elevated activity of bFGF autocrine loop may play an important role in the development and progression of bladder cancer. bFGF and FGFR 1 may be valueful predictors for biological behavitor and prognosis of bladder cancer.

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Objective To investigate the roles of basic fibroblast growth factor (bFGF) autocrine loop in pathogenesis of bladder cancer. Methods Expressions of bFGF and its receptor FGFR 1 and phosphotyrosine protein (P Tyr) were examined by immunohistochemistry methods in 72 cases with bladder and 16 specimens of normal bladder tissue. Results Higher expressions of bFGF, FGFR 1 and P Tyr were found in bladder than those in normal tissues, respectively. Expressions of bFGF and FGFR 1 were assocition with tumor grade, stage and recurrence. There were significantly relating expressions among bFGF, FGFR 1 and P Tyr in bladder cancer. Conclusion Abnormally elevated activity of bFGF autocrine loop may play an important role in the development and progression of bladder cancer. bFGF and FGFR 1 may be valueful predictors for biological behavitor and prognosis of bladder cancer.

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Available abstract

Objective To investigate the roles of basic fibroblast growth factor (bFGF) autocrine loop in pathogenesis of bladder cancer. Methods Expressions of bFGF and its receptor FGFR 1 and phosphotyrosine protein (P Tyr) were examined by immunohistochemistry methods in 72 cases with bladder and 16 specimens of normal bladder tissue. Results Higher expressions of bFGF, FGFR 1 and P Tyr were found in bladder than those in normal tissues, respectively. Expressions of bFGF and FGFR 1 were assocition with tumor grade, stage and recurrence. There were significantly relating expressions among bFGF, FGFR 1 and P Tyr in bladder cancer. Conclusion Abnormally elevated activity of bFGF autocrine loop may play an important role in the development and progression of bladder cancer. bFGF and FGFR 1 may be valueful predictors for biological behavitor and prognosis of bladder cancer.

Key concepts: Autocrine signalling, Fibroblast growth factor receptor, Medicine, Bladder cancer, Basic fibroblast growth factor, Immunohistochemistry, Fibroblast growth factor, Cancer

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Study of Expressions of bFGF and FGFR 1 as Well as Levelof FGFR 1 Activity in Bladder Cancer — Research Paper | ScholarLens