Apoptosis and Related Fas Gene Expression in Testicular Carcinona

Objective To explore the role of apoptosis and related genes Fas in carcinogenesis and development of testicular carcinoma.Methods Apoptosis and Fas expression were detected with TdT-mediated dUTP-biotin nick,labeling(TUNEL) and flow cytomytry,celluar immunofluoresence technique in 56 cases of germ cell testicular tumors.Results Apoptosis index was well correlated with the pathological type and lymph node metastases(P0.05).Fas protein expression was correlated with the pathological type,but without a significant difference(P0.05).The apoptosis index was consistently changed with Fas protein expression(P0.05).Conclusion The abnormal cell apoptosis and Fas overexpression play an important role in the carcinogenesis of testicular carcinoma.