Effects of genistein on glucose and lipid metabolism and the expression of serum leptin and resistin in ovariectomized SD rats

To delineate the effects of ovariectomy(OVX) and genistein treatment on the levels of glucose,insulin,total cholesterol,LDL,HDL,triglycerides,serum leptin and resistin,female SD rats(12-week old) were divided into three groups,control(Sham),OVX and OVX treated with genistein(OVX+Gen)(n=7,each group).After operation for 10 days,rats were treated with genistein(ip,0.2 mg per day)(OVX+Gen) and vehicle(Sham and OVX rats) for 30 days.The pathological conditions of the uterus,and the levels of glucose,total cholesterol,LDL,HDL,triglycerides,serum leptin and resistin were analyzed.The results indicated that OVX upregulated the levels of total cholesterol,LDL and HDL,but showed no effect on the levels of insulin,blood glucose,triglyceride,serum leptin and resistin.Although the treatment with genistein did not change the levels of insulin,blood glucose,total cholesterol,triglyceride,LDL,HDL,serum leptin and resistin,it stimulated the proliferation of endometrial epithelial cells.The results suggest that genistein could promote the proliferation of endometrial epithelial cells,but show no effects of on the glucose and lipid metabolism,and the levels of serum leptin and resistin in ovariectomized female rats.