Analysis of Ambulatory Blood Pressure and Heart Rate Variability in Patients with Chronic Kidney Disease with Hypertension

Objective To investigate the characteristics of changes of ambulatory blood pressure and heart rate variability(HRV)in patients with chronic kidney disease with hypertension(HCKD).Methods 56 patients with HCKD,44 patients with essential hypertension(EH)and 43 normal subjects were selected randomly,and their ambulatory blood pressure and dynamic electrocardiogram were simultaneously monitored to compare and analyze their ambulatory blood pressure parameter and the varied characteristics of HRV.Results Compared with EH group,the ambulatory blood pressure parameters including mean24DBP,meanNSBP and meanNDBP were higher significantly in HCKD group(P0.05),and the ratio of non-dipper hypertension(89.28%)in HCKD group was higher than EH group(P0.05).However,the HRV time domain indexes including SDNN,SDANN,rMSSD and PNN50 were significantly lower than those in EH group(P0.05).Conclusion The average blood pressure of the HCKD patients in 24 hours and at night increase with abnormal circadian rhythm of blood pressure and significant decrease of HRV.