The clinical study of carvedilol combined with valsartan on chronic heart failure

Objective To observe and investigate therapeutic effect and security of carvedilol treatment combined with valsartan on chronic heart failure. Methods 197 patients with chronic heart failure were chose in the period from May 2007 to October 2011 in our hospital and randomly divided into two groups including control group (99 patients) with valsartan treatment and experimental group (98 patients) with carvedilol treatment combined with valsartan both for 6 months,and after treatment the therapeutic effects and adverse effects were assessed. Results The total effective rate of experimental group were significantly higher than control group(P0.05). The improvement degree of blood pressure, heart rate, LVEF, LVD, LVS, and SV of experimental group were also significantly better than control group(P0.05). There was no significant difference in the incidence of adverse effects between control group and experimental group(P0.05).Conclusion The carvedilol treatment combined with valsartan on chronic heart failure possess excellent clinical effect, can effectively improve cardiac function, have no serious adverse effects, and is worthy of clinical application.