The effect evaluation of electroacupuncture improving therapeutic effects and decreasing the side-effects of Paroxetine for mild or moderate depression patients

Objective: To observe the clinical therapeutic efficacy,disease severity and adverse reactions of electroacupuncture on mild or moderate depression combining with Paroxetine and the effect of electroacupuncture on the side-effects of Paroxetine treatment for depression.Methods: Fifty-five patients with mild or moderate depression were randomly divided into group A(Paroxetine group,29 patients)and group B(Electroacupuncture combining with Paroxetine group,26 patients).The therapeutic period for the two groups was 6 weeks.Hamilton Depression Rating Scale for Depression(HAMD),Rating Scale for Side Effects(SERS) and Clinical Global Impression Tables(CGI) were used to evaluate the efficacy before the research and after treatment on 1 week,2 weeks,4 weeks,6 weeks.Results: After two weeks' treatment,HAMD scores of group A were significant different compared with the beginning of the research(P0.05);HAMD scores of group B after one-week's treatment were significant different compared with the beginning of the research(P0.05);After six weeks,treatment,there were no sigficiant differences between group A and group B.Total effective rate of HAMD for group A was 71.4%,Total effective rate of HAMD for group B was 88%;Total effective rate of HAMD was significantly different between the two groups(P0.05).SERS scores for group A was no different compared with the beginning of the research.SERS scores for group B were different compared with the beginning of the research for the fourth week(P0.05).After 6 weeks' treatment,CGI scores were significant differences between group A and group B in disease severity,efficacy comments and efficacy index(P0.05).The Evaluation resluts of CGI showed that the illness severity,assessment of efficacy and therapeuticindex between two groups all had significant differences(P0.05).Conclusions: Electroacupuncture could improve Paroxetine efficacy on mild or moderate depression.At the same time,electroacupuncture combining with Paroxetine could significantly decrease the side-effects of Paroxetine.