2002•Chinese Journal of Clinkal Oncology and RehabilitationRequires access

Clinical observation on radiotherapy plus chemotherapy in advanced nasopharyngeal carcinoma

Xiang Qi-chang

Abstract

ObjectiveTo evaluate the value of chemotherapy with radiotherapy in advanced nasopharyngeal carcinoma.Methods52 patients were divided randomly into two groups.Radiotherapy group(26 cases) was only treated with DT70～74Gy/7～7.5W in nasopharyngeal and DT50～65Gy/5～6.5W in the neck.Chemoradiotherapy group(26 cases) received chemotherapy with DDP+5FU during the first week and the fifth week.ResultsThe 1-,2- and 3-year survival rates were 88.46%?73.08%?53.85% in radiotherapy group and 92.31%?80.77%?73.08% in chemoradiotherapy group respectively.No significant difference was found between the two groups in 1- and 2-year survival rates,but there was in 3-year survival rate.ConclusionRadiotherapy with chemotherapy can increase the survival rates and decrease the distant metastasis in advanced nasopharyngeal carcinoma.

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Key concepts: Nasopharyngeal carcinoma, Medicine, Radiation therapy, Chemotherapy, Chemoradiotherapy, Survival rate, Internal medicine, Distant metastasis