Clinical and Electrophysiological Analysis of Guillain-Barre Syndrome

Objective:To study the clinical and electrophysiological features of patients with Guillian-Barre Syndrome (GBS) and evaluate its significance in diagnosis. Methods: Retrospective analysis was performed to analyze the clinical and electrophysiological examination data of 38 patients with GBS diagnosed in our hospital from 2001 to 2007. The association between their clinical characteristics and motor conduction velocity(MCV),sensory conductive velocity(SCV),F wave and EMG were investigated. Results: The abnormal rate of MCV(42.86%) was higher than that of SCV(26.19%) (P0.05). The abnormal rate of distant MCV of lower extremities (34.52%) was higher than that of upper extremities (24.4%)(P0.05). F wave abnormality was 43.33%. The degree of nerve conduction abnormalities correlated positively with concentrations of proteins in CSF. 51.35% of EMG revealed the neurogenic damage. There was no significant difference between the rate of fibrillation potential and positive sharp wave in proximal and that of distal muscles of limbs. Conclusion: Nerve demyelination and secondary axonal damage in patients with Guillian-Barre Syndrome (GBS) can be dectected by electrophysiological study. The injury of distal motor nerve is more severe than the sensory nerve. The damage of nerve in the lower limbs is more severe than the upper limbs.