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2008•Pharmaceutical Journal of Chinese People's Liberation ArmyRequires access

Determination of Naphazoline Hydrochloride in Triamcinolone Acetonide Acetate and Chloramphenicol Solution

Bao Rui

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Abstract

Aim To establish an HPLC method for the determination of Naphazoline Hydrochloride in Triamcinolone Acetonide Acetate and Chloramphenicol Solution.Methods The determination was conducted on a C18 column with column temperature at ambient temperature. The mobile phase consisted of methanol-water-triethyamine(50∶50∶0.25)(adjust pH to 4.0 with phosphoric acid)with flow rate at 1.0ml/min.The detection wavelength was set at 280nm and the sample size was 20μl.Results The linear range of Naphazoline Hydrochloride was at 65.7～157.4μg·ml-1(r=0.999 9).The average recovery was 99.4%(RSD=1.6% ).Conclusion The method is simple,rapid,accurate,and suitable for quality control of Naphazoline Hydrochloride in Triamcinolone Acetonide Acetate and Chloramphenicol Solution.

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Aim To establish an HPLC method for the determination of Naphazoline Hydrochloride in Triamcinolone Acetonide Acetate and Chloramphenicol Solution.Methods The determination was conducted on a C18 column with column temperature at ambient temperature. The mobile phase consisted of methanol-water-triethyamine(50∶50∶0.25)(adjust pH to 4.0 with phosphoric acid)with flow rate at 1.0ml/min.The detection wavelength was set at 280nm and the sample size was 20μl.Results The linear range of Naphazoline Hydrochloride was at 65.7～157.4μg·ml-1(r=0.999 9).The average recovery was 99.4%(RSD=1.6% ).Conclusion The method is simple,rapid,accurate,and suitable for quality control of Naphazoline Hydrochloride in Triamcinolone Acetonide Acetate and Chloramphenicol Solution.

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Available abstract

Aim To establish an HPLC method for the determination of Naphazoline Hydrochloride in Triamcinolone Acetonide Acetate and Chloramphenicol Solution.Methods The determination was conducted on a C18 column with column temperature at ambient temperature. The mobile phase consisted of methanol-water-triethyamine(50∶50∶0.25)(adjust pH to 4.0 with phosphoric acid)with flow rate at 1.0ml/min.The detection wavelength was set at 280nm and the sample size was 20μl.Results The linear range of Naphazoline Hydrochloride was at 65.7～157.4μg·ml-1(r=0.999 9).The average recovery was 99.4%(RSD=1.6% ).Conclusion The method is simple,rapid,accurate,and suitable for quality control of Naphazoline Hydrochloride in Triamcinolone Acetonide Acetate and Chloramphenicol Solution.

Key concepts: Chromatography, Triamcinolone acetonide, Chemistry, Phosphoric acid, Medicine, Organic chemistry, Surgery

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