2008•Liaoning Zhongyiyao Daxue xuebaoRequires access

Influence of JieYouFang in Expression of BDNF and TrkB in Hippocampus of Rat Models with Depression

Zheng San-xia

Abstract

Objective :To observe the influence of JieYouFang in expression of BDNF and TrkB in hippocampus of rat models with depression.Method :Establish cums depression rat models and observe the influence of JieYouFang in expression of BDNF and TrkB in hippocampus by immunohistochemistry methods.Result :The expression of BDNF and TrkB in hippocampus in rat models with depression were depressed compared to normal rats.JieYouFang can improve the expression of BDNF and TrkB.Conclussion :The anti-depression effect of JieYouFang may be related to its function of improving the expression of BDNF and TrkB.

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Key concepts: Tropomyosin receptor kinase B, Hippocampus, Medicine, Depression (economics), Brain-derived neurotrophic factor, Internal medicine, Neuroscience, Immunohistochemistry