The Expression and Significance of CDK-2 in Nasopharyngeal Carcinoma

Objective The propose of the research was focused on the expression levels of CDK2 in the tissues of nasopharyngeal carcinoma and chronic inflammation nasopharyngeal membrane.And it may relate to the pathogenesis and clinical significance of nasopharyngeal carcinoma which had been observed in the field of cell cycle.Methods Immunohistochemistry(sp) was used to examine the expression levels of CDK2 protein in the tissues of nasopharyngeal carcinoma and chronic inflammation nasopharyngeal membrane.Results Most of the CDK2 protein positive expression was found in cell nucleus,but some was found in the kytoplasm and its color was brown yellow or dark brown.The positive expression rate of nasopharyngeal carcinoma from 62 patients was 69.40%(43/62),and that of the chronic inflammation nasopharyngeal membrane was 32.0%(9/28).The difference of the two groups was found statistical significance(P0.05);the expression levels of CDK2 were related to the differential degree,the range of lymph node metastases and clinical staging of nasopharyngeal carcinoma,the difference was been found statistical significance(P0.05).Conclusion The expression levels of CDK2 in the tissues of nasopharyngeal carcinoma was obviously higher than that of the chronic inflammation nasopharyngeal membrane,which means CDK2 may relate to the genesis and development of nasopharyngeal carcinoma.The expression level of CDK2 was related to the differential degree,the range of lymph node metastases and clinical staging of nasopharyngeal carcinoma.