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Electrophysiological Evaluation of Basic Fibroblast Growth Factor on Delayed Peripheral Nerve Regeneration

Liang Lun-gao

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Abstract

Objective:To evaluate the effect of exogenous basic fibroblast growth factor (BFGF) on the physiological function recovery of delayed peripheral nerve regeneration. Method:Trasection was made on the right sciatic nerve in 50 Sprague-Dawley rats. Repairing operation was made after 12 weeks of transection. 25 rats in the experiment group was injected BFGF and 25 rats in the control group was injected only saline. All animals were observed through nerve electrophysiological examination and histological examination at 2, 4, 6, 8 and 12 weeks after the repairing operation. Result:The motor nerve conductive velocity, the muscle evoked action potential, the rate of the muscle wet weight of triceps surae muscle in experimental group were significantly better than those in the control group. Conclusion:BFGF can improve the physiological function recovery of the delayed peripheral nerve regeneration.

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What this paper is about

Objective:To evaluate the effect of exogenous basic fibroblast growth factor (BFGF) on the physiological function recovery of delayed peripheral nerve regeneration. Method:Trasection was made on the right sciatic nerve in 50 Sprague-Dawley rats. Repairing operation was made after 12 weeks of transection. 25 rats in the experiment group was injected BFGF and 25 rats in the control group was injected only saline. All animals were observed through nerve electrophysiological examination and histological examination at 2, 4, 6, 8 and 12 weeks after the repairing operation. Result:The motor nerve conductive velocity, the muscle evoked action potential, the rate of the muscle wet weight of triceps surae muscle in experimental group were significantly better than those in the control group. Conclusion:BFGF can improve the physiological function recovery of the delayed peripheral nerve regeneration.

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Available abstract

Objective:To evaluate the effect of exogenous basic fibroblast growth factor (BFGF) on the physiological function recovery of delayed peripheral nerve regeneration. Method:Trasection was made on the right sciatic nerve in 50 Sprague-Dawley rats. Repairing operation was made after 12 weeks of transection. 25 rats in the experiment group was injected BFGF and 25 rats in the control group was injected only saline. All animals were observed through nerve electrophysiological examination and histological examination at 2, 4, 6, 8 and 12 weeks after the repairing operation. Result:The motor nerve conductive velocity, the muscle evoked action potential, the rate of the muscle wet weight of triceps surae muscle in experimental group were significantly better than those in the control group. Conclusion:BFGF can improve the physiological function recovery of the delayed peripheral nerve regeneration.

Key concepts: Regeneration (biology), Basic fibroblast growth factor, Sciatic nerve, Electrophysiology, Peripheral, Peripheral nerve, Medicine, Saline

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Electrophysiological Evaluation of Basic Fibroblast Growth Factor on Delayed Peripheral Nerve Regeneration — Research Paper | ScholarLens