Value of cystatin C for the evaluation of glomerular filtration rate in children with renal disease

Objective To investigate the practical value of serum cystatin c(Cys c)for the evaluation of glomerular filtration rate(GFR)in renal disease children.Methods Fifty children with renal disease and seventy-five without renal disease were enrolled.Serum Cys C and creatinine concentrations(Scr)were measured,24-hours creatinine clearances(GFRCCR)calculated with Schwartz(ccr)formula were used as the indicator of glomerular filtration rate(GFR).Results There were great significant differences in Cys C concentrations between ⅠandⅡ renal disease children(t = 9.15,P 0.01),also between renal disease and without renal disease children.On evaluation of the correlation study for renal function in renal disease children,although significant relationships were found between GFR 1/Cys C and GFR-ccr,1/Scr(r = 0.886、0.451、0.742,all P 0.05)levels,the best correlation of GFR was found with Cys C.ROC analysis showed that the diagnostic accuracies of Cys C were significantly higher than those of Scr and Schwartz formula when GFR was less than 80 mL/min(z = 2.97,P 0.01;z = 2.38,P 0.05).Conclusion Cys C can better reveal the damage to renal filtration function in children than Scr and GFR-ccr,which is suggested to be used as the GFR indicator for children with renal disease.