2003•Dongwuxue zazhiRequires access

Immunological Characteristics and Protective Immunity of the Trichinella spiralis Ts87 Antigen

Yamg Jing, Zhu Xinping, Ya-ping Yang, Liping Lei

Abstract

The immunological characteristics and protective immunity of the purified recombinant protein Ts87 were analyzed by Western blot and ELISA. The Ts87 antigen could be recognized by infected rabbit sera, infected swine sera, infected human sera and antisera against Ts87 by Western blot and ELISA. The immunoprotective effect of the Ts87 antigen of Trichinella spiralis was studied by a challenge experiment. Compared with a control group, numbers of larvae in the muscle of immunized mice decreased by 29%. The results showed that the Ts87 antigen might be both a promising immunodiagnosis antigen and a vaccine candidate for Trichinella spiralis.

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Key concepts: Trichinella spiralis, Antigen, Western blot, Trichinella, Trichinosis, Biology, Antiserum, Immunity