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2007•Zhongguo shiyong fuke yu chanke zazhiRequires access

A diagnostic and monitoring value of lysophosphatidic acid for ovarian epithelial cancer

Li Shi

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Abstract

Objective To investigate the value of lysophosphatidic acid for diagnosis and monitoring of ovarian epithelial cancer.Methods We measured LPA and CA125 in plasma and in ascitic fluid from ovarian epithelial cancer(n=40) with preoperative and postoperative and benign ovarian neoplasm(n=20) from 2005-04 to 2005-10 in the Fourth Hospital of Hebei Medical University.Results Patients with ovarian epithelial cancer had significantly higher plasma and ascitic fluid LPA levels compared with the benign control group(P0.01 P0.01),and postoperative LPA levels were significantly lower than preoperative levels(P0.01).The diagnostic sensitivity and specificity of plasma LPA for stage Ⅰovarian epithelial cancer were 75% and 80%,while CA125 was 50% and 40%.Conclusion LPA levels may be a new biomarker for detecting early-stage ovarian epithelial cancer.LPA levels appear useful as monitoring and prognostic biomarkers of ovarian epithelial cancer.

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Objective To investigate the value of lysophosphatidic acid for diagnosis and monitoring of ovarian epithelial cancer.Methods We measured LPA and CA125 in plasma and in ascitic fluid from ovarian epithelial cancer(n=40) with preoperative and postoperative and benign ovarian neoplasm(n=20) from 2005-04 to 2005-10 in the Fourth Hospital of Hebei Medical University.Results Patients with ovarian epithelial cancer had significantly higher plasma and ascitic fluid LPA levels compared with the benign control group(P0.01 P0.01),and postoperative LPA levels were significantly lower than preoperative levels(P0.01).The diagnostic sensitivity and specificity of plasma LPA for stage Ⅰovarian epithelial cancer were 75% and 80%,while CA125 was 50% and 40%.Conclusion LPA levels may be a new biomarker for detecting early-stage ovarian epithelial cancer.LPA levels appear useful as monitoring and prognostic biomarkers of ovarian epithelial cancer.

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Available abstract

Objective To investigate the value of lysophosphatidic acid for diagnosis and monitoring of ovarian epithelial cancer.Methods We measured LPA and CA125 in plasma and in ascitic fluid from ovarian epithelial cancer(n=40) with preoperative and postoperative and benign ovarian neoplasm(n=20) from 2005-04 to 2005-10 in the Fourth Hospital of Hebei Medical University.Results Patients with ovarian epithelial cancer had significantly higher plasma and ascitic fluid LPA levels compared with the benign control group(P0.01 P0.01),and postoperative LPA levels were significantly lower than preoperative levels(P0.01).The diagnostic sensitivity and specificity of plasma LPA for stage Ⅰovarian epithelial cancer were 75% and 80%,while CA125 was 50% and 40%.Conclusion LPA levels may be a new biomarker for detecting early-stage ovarian epithelial cancer.LPA levels appear useful as monitoring and prognostic biomarkers of ovarian epithelial cancer.

Key concepts: Lysophosphatidic acid, Ovarian cancer, Epithelial ovarian cancer, Medicine, Stage (stratigraphy), Biomarker, Internal medicine, Cancer

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