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[Heat shock response in guinea pigs cochlea with gentamicin ototoxicity].

Yue-Qiu Ni, Hao Tang, FU Wen-shuang

Abstract

AIM: To explore the effects of gentamicin ototoxicity on the expression of heat shock protein 70 in guinea pigs cochlea. METHODS: We used immunohistochemistry staining and image quantitative analysis system, combined with auditory brainstem response (ABR) measurement to investigate the change on the expression of HSP70 in guinea pigs cochlea of gentamicin ototoxicity. RESULTS: The levels of HSP70 immunoreactivity in guinea pigs cochlea of experimental animals were high including Corti's organ, stria vascularis, medial spiral limbus, spiral ganglion cells and the threshold of ABR was in high correlation with the expression of HSP70 ([ r] > 0.8, P < 0.01). CONCLUSION: Gentamicin can induce expression of HSP 70 in guinea pigs cochlea and protect hearing function.

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Key concepts: Spiral ganglion, Cochlea, Organ of Corti, Ototoxicity, Gentamicin, Guinea pig, Auditory brainstem response, Shock (circulatory)