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Effect of the Compounds from Taxus chinensis var. mairei and T. cuspidata on the Proliferation of Human Breast Cancer Cells

Lei‐Ming Ren

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Abstract

MTT assays were used to study the effects of 10 compounds from Taxus chinensis var.mairei and T.cuspidata on the proliferation of MCF-7 human breast cancer cultured cells in vitro in this study.After treated with compounds(1-10)(10-9-10-5 mol/L) for 48 h and 72 h,compound 4 produced a significant inhibition effect on MCF-7 cells at 10-7-10-5 mol/L(P0.01),and the inhibitory rate was 29.8%,46.4%,51.8% or 43.6%,61.2%,63.2%,respectively,nearly similar to taxol at the same concentration.During the period of 24-72 h,the inhibition effect was time-dependent.Compound 2 showed a significant inhibition on MCF-7 cells only at 10-5 mol/L (P0.01),and the inhibitory rate was 44.4% and 49.6%.Consequently,compounds 2 and 4,the analogues of bacctin III,inhibited the proliferation of MCF-7 breast cancer cells significantly,and compound 4 had the higher activity among them,nearly similar to taxol.

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What this paper is about

MTT assays were used to study the effects of 10 compounds from Taxus chinensis var.mairei and T.cuspidata on the proliferation of MCF-7 human breast cancer cultured cells in vitro in this study.After treated with compounds(1-10)(10-9-10-5 mol/L) for 48 h and 72 h,compound 4 produced a significant inhibition effect on MCF-7 cells at 10-7-10-5 mol/L(P0.01),and the inhibitory rate was 29.8%,46.4%,51.8% or 43.6%,61.2%,63.2%,respectively,nearly similar to taxol at the same concentration.During the period of 24-72 h,the inhibition effect was time-dependent.Compound 2 showed a significant inhibition on MCF-7 cells only at 10-5 mol/L (P0.01),and the inhibitory rate was 44.4% and 49.6%.Consequently,compounds 2 and 4,the analogues of bacctin III,inhibited the proliferation of MCF-7 breast cancer cells significantly,and compound 4 had the higher activity among them,nearly similar to taxol.

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Available abstract

MTT assays were used to study the effects of 10 compounds from Taxus chinensis var.mairei and T.cuspidata on the proliferation of MCF-7 human breast cancer cultured cells in vitro in this study.After treated with compounds(1-10)(10-9-10-5 mol/L) for 48 h and 72 h,compound 4 produced a significant inhibition effect on MCF-7 cells at 10-7-10-5 mol/L(P0.01),and the inhibitory rate was 29.8%,46.4%,51.8% or 43.6%,61.2%,63.2%,respectively,nearly similar to taxol at the same concentration.During the period of 24-72 h,the inhibition effect was time-dependent.Compound 2 showed a significant inhibition on MCF-7 cells only at 10-5 mol/L (P0.01),and the inhibitory rate was 44.4% and 49.6%.Consequently,compounds 2 and 4,the analogues of bacctin III,inhibited the proliferation of MCF-7 breast cancer cells significantly,and compound 4 had the higher activity among them,nearly similar to taxol.

Key concepts: Taxus, In vitro, MCF-7, Human breast, MTT assay, Cancer cell, Chemistry, Growth inhibition

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Effect of the Compounds from Taxus chinensis var. mairei and T. cuspidata on the Proliferation of Human Breast Cancer Cells — Research Paper | ScholarLens