2009•Chinese Journal of Clinical NeurosciencesRequires access

Association of APOA5 Gene c553G/T Polymorphism with Cerebral Infarction

Chen Wei

Abstract

Aim:To investigate the relationship between the polymorphism of APOlipoprotein A5 gene c553G/T and cerebral infarction.Methods:140 patients with cerebral infarction and 129 healthy controls were collected to determine the genotypes by using polymerase chain reaction-restriction fragment length polymorphisms.Results:TT homozygotes and GT heterozygotes had a significantly higher triglyceride, cholesterol,LDL levels and lower HDL in both case group and control group;c553T genotype was an independent risk factor with CE(OR=6.269,P=0.016).Conclusion:APOA5 c553G/T polymorphism has association with plasma triglyceride,cholesterol,HDL,LDL levels.APOA5 c553T genotype may be an independent risk factor with cardioembolism.

About this research paper

What this paper is about

Why it matters

OpenAlex reports 1 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Genotype, Internal medicine, Triglyceride, Cerebral infarction, Allele, Apolipoprotein B, Heterozygote advantage, Polymorphism (computer science)