2012•Journal of Cardiovascular and Pulmonary DiseasesRequires access
Protection of noninvasive limb ischemic preconditioning in different time windows of acute myocardial infarction Rats
Keji Liang
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Abstract
Objective:To observe the protective effects of noninvasive limb ischemic conditioning on the myocardial ischemia/reperfusion(I/R) injury in different time windows of acute myocardial infarction(AMI) rats.Methods:All wistar rats were randomly divided into four groups(n=10 in each group):(1)Myocardial ischemia /reperfusion group(group A),limb ischemic preconditioning before AMI group(group B),limb ischemic preconditioning before reperfusion group(group C),limb ischemic preconditioning during reperfusion group(group D).We recorded the ST-segment during AMI and reperfusion,and measured myocardial area at risk(AAR),myocardial infarcted area(IA),IA/LV,IA/AAR,MB isoenzyme of creatine kinase(CK-MB) after 3 h of reperfusion.Result:The elevation of ST-segment is decreased,and IA,IA/AAR,CK-MB are significantly less in group B,C and D as compared to group A(P0.01).Conclusion:The noninvasive limb ischemic conditioning in different time windows of AMI rats can prevent myocardial ischemia-reperfusion injury.