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2005•Acta Acadimae Qingdao UmvesitatisRequires access

EXPRESSION OF COLLAGEN TYPE-IV IN HUMAN LUMBAR INTERVERTEBRAL DISCS

HU You-gu

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Abstract

Objective To investigate the expression of type-Ⅳ collagen and its relationship with degeneration of intervertebral disc. Methods The expressions of type-Ⅳ collagen in frozen sections of the discs collected from an operation for degenerative lesion and different age-group subjects were analyzed by using LAB immunohistochemical technology. Results Collagen type Ⅳ presented only in the discs of adolescents, which surrounded mainly the chondrocyte-like cells of the nucleus pulposus. The proportion of positively stained cells increased significantly with age. No positive reaction signals were found in age other groups. (Conclusion Type)-Ⅳ collagen occurs in the disc of adolescents is an early cellular reaction to harmful stimulation, which can be served as a biomarker of early degeneration of human lumbar intervertebral discs.

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What this paper is about

Objective To investigate the expression of type-Ⅳ collagen and its relationship with degeneration of intervertebral disc. Methods The expressions of type-Ⅳ collagen in frozen sections of the discs collected from an operation for degenerative lesion and different age-group subjects were analyzed by using LAB immunohistochemical technology. Results Collagen type Ⅳ presented only in the discs of adolescents, which surrounded mainly the chondrocyte-like cells of the nucleus pulposus. The proportion of positively stained cells increased significantly with age. No positive reaction signals were found in age other groups. (Conclusion Type)-Ⅳ collagen occurs in the disc of adolescents is an early cellular reaction to harmful stimulation, which can be served as a biomarker of early degeneration of human lumbar intervertebral discs.

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Available abstract

Objective To investigate the expression of type-Ⅳ collagen and its relationship with degeneration of intervertebral disc. Methods The expressions of type-Ⅳ collagen in frozen sections of the discs collected from an operation for degenerative lesion and different age-group subjects were analyzed by using LAB immunohistochemical technology. Results Collagen type Ⅳ presented only in the discs of adolescents, which surrounded mainly the chondrocyte-like cells of the nucleus pulposus. The proportion of positively stained cells increased significantly with age. No positive reaction signals were found in age other groups. (Conclusion Type)-Ⅳ collagen occurs in the disc of adolescents is an early cellular reaction to harmful stimulation, which can be served as a biomarker of early degeneration of human lumbar intervertebral discs.

Key concepts: Degeneration (medical), Immunohistochemistry, Intervertebral disc, Type I collagen, Type II collagen, Pathology, Lumbar, Anatomy

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EXPRESSION OF COLLAGEN TYPE-IV IN HUMAN LUMBAR INTERVERTEBRAL DISCS — Research Paper | ScholarLens