Effects of continuous positive airway pressure therapy on patients with obstructive sleep apnea hypopnea syndrome and type 2 diabetes

Objective To observe the effects of continuous positive airway pressure(CPAP) therapy on insulin resistance(IR) of patients with obstructive sleep apnea hypopnea syndrome(OSAHS) and type 2 diabetes.Methods Forty-six patients with OSAHS and type 2 diabetes were randomly divided into two groups: control group(n=22) received the conventional treatment,while observation group(n=24) accepted additional CPAP therapy.IR was evaluated with homeostasis model assessment(HOMA) index.Clinical parameters of all patients were measured before and 1,3 and 6 months after treatment.Results Compared with pretreatment and control group at same time points,the minimal SaO2 level increased 1 month post treatment(P0.01),apnea hypopnea index(AHI) decreased 3 months post treatment(P0.01),and fasting insulin level and HOMA index reduced 6 months post treatment(P0.01) in observation group.Conclusion Long-term CPAP treatment can obviously improve the IR in patients with OSAHS and type 2 diabetes.