Contrast-enhanced Ultrasound in the Diagnosis of Breast Intraductal Papilloma

Objective To evaluate the usefulness of contrast-enhanced ultrasound( CEUS) in the diagnosis of breast intraductal papilloma.Methods CEUS was performed after administration of sulphur hexafluoride microbubbles( SonoVue) in 96 patients scheduled for surgical tumor removal among whom 11 were histologically confirmed to be intraductal papillomas.The enhancement morphologies were classified as non-enhancement,peripheral enhancement,homogeneous enhancement,regional enhancement,and heterogeneous enhancement.The histologic slides were reviewed and compared with CEUS findings.Results Of all 11 intraductal papillomas,6 cases were detected by routine ultrasound and the sizes of lesions were 1.6-3.9 cm; 4 cases were detected by CEUS with a mode of hemogeneous enhancement,and the sizes of lesions were 0.5-1.2 cm.Homogeneous enhancement,regional enhancement,and non-enhancement were found in 6 cases( 54.5%),4 cases( 36.4%),and 1 case( 9.1%),respectively.The contrast enhanced area corresponded to the intraductal papiloma,whereas the non-enhanced area corresponded to the ductal ectasis,fibrosis.Conclusion Intraductal papilloma mainly shows homogeneous or regional enhancement,and the CEUS findings correlate with histologic features.