Effects of aerobic training on skeletal muscle metabolic enzymes in different aging rats

Objective:To provide theoretical evidence for ensuring the most suitable time of endurance training for developing the aerobic capacity by studying the effect on the active of metabolic enzyme of skeletal muscle of mice at different weeks old.Methods: Total 48 male mice were at three different levels of weeks old,16 mice were 4 weeks old,as many as 8 weeks old and 12 weeks old.Each the 16 mice were randomly divided into tow groups,One group swam at middling strength,and the other group was as a control group.Each swimming group swam for 25 minutes a day in the first four days as fitness.And then the swimming groups swam for 50 minutes a day.Every week,the time of swimming was lengthened 10 minutes,and after every six days,the mice swam had a rest for a day.The total time for training was 8 weeks.Enzymohistochemistry was used to study the activity of SDH,LDH,ATPase and the amount of PAS in skeletal muscle of mice.Results: After 8 weeks training,compared with the control groups,the activity of SDH in both 4 weeks old swimming group and 8 weeks old swimming group were highly significantly increased(P0.01),the activity of SDH in 12 weeks old swimming group was significantly increased(P0.05);Compared with the control groups,the activity of LDH and ATPase in both 4 weeks old swimming group and 8 weeks old swimming group were significantly decreased(P0.05),but no difference was existed between the tow groups at 12 weeks old;Compared with the control groups,the amount of PAS in all swimming groups were significantly increased(P0.05). Conclusion: The endurance training helped to develop the aerobic capacity of mice in all three swimming groups,especially both the 4 weeks old swimming group and 8 weeks old swimming group.On the other hand,the endurance training reduced the glycolysis capacity of skeletal muscle of mice in both the 4 weeks old swimming group and 8 weeks old swimming group,but the effect of the endurance training on glycolysis capacity of skeletal muscle of mice in the 12 weeks old group was not sure.Therefore,young children period was the best time to have aerobic endurance training for developing the aerobic capacity.