Rabbit Model of Delayed Facial Paralysis and Drug Intervention

Objective: Optimization of modeling of delayed facial paralysis.The neuroprotective effect of several drugs were observed.Methods: Forty-eight rabbits were assigned to A,B,C,D 4 experimental groups,with one side of the facial nerve to the experimental treatment,and the other side of self-control.A: The cisternal section of the facial nerve was injured by clamp.B: Injection of arterial blood to the cerebellopontine angle to induce vasospasm.C: treatment factor = group A + group B.D group: C group plus the application of drug(prednisone + SM + vitamin B1 + vitamin B12) intervention.The rabbit facial paralysis was observed.And facial nerve biopsy was done.The incidence of delayed facial paralysis,duration and prognosis were compared.Results: The incidence of facial paralysis: in group A 6 rabbits(6 / 11,54.5%) had delayed facial paralysis;the average duration of facial paralysis was 13.2 days.In group B,2(2 / 12,16.7%) had delayed facial paralysis,the average duration was 8 days.In group C 6(6 / 12,50%) had delayed facial paralysis,and the average duration was 14.3 days.In group D 4(4 / 12,33.33%) had delayed facial paralysis,the average duration was 6 days.There was no facial paralysis in all self-control sides.Pathology: Nerve fiber edema was seen in each group;groups A,C showed a high degree of edema,with nerve bundles around the structural disorder;group B showed small blood vessels within the nerve,and mild edema com-pared with groups A,C;group D showed a slight edema change.Conclusion: Group C had higher risk of delayed facial paralysis,so it is a better model.Combination of prednisone,Salvia,vitamin B1,vitamin B12,although not able to prevent the occurrence of delayed fa-cial paralysis,but the duration of the delayed facial paralysis was significantly shortened.